abstract：:This study investigated the correlation between fluoroquinolone (ciprofloxacin or levofloxacin) use and rates of fluoroquinolone resistance in Pseudomonas aeruginosa isolates from patients with nosocomial infection at a medical centre in Taiwan. Antibiotic utilisation data were extracted on a monthly basis from the in...

journal_title：International journal of antimicrobial agents

authors： Lee YJ,Liu HY,Lin YC,Sun KL,Chun CL,Hsueh PR

更新日期：2010-03-01 00:00:00

abstract：:The Chinese Meropenem Surveillance Study (CMSS) programme was initiated in 2003 with the aim of monitoring the antimicrobial activity of broad-spectrum agents against nosocomial Gram-negative bacilli in China. From 2003 to 2008, a total of 3892 isolates were collected from 10 teaching hospitals. The minimum inhibitory...

journal_title：International journal of antimicrobial agents

authors： Wang H,Chen M,Ni Y,Liu Y,Sun H,Yu Y,Yu X,Mei Y,Liu M,Sun Z,Chu Y,Hu Z,Huang X

更新日期：2010-03-01 00:00:00

abstract：:We evaluated the antimicrobial activity of fusidic acid (CEM-102) against 1140 clinical strains of Gram-positive bacteria obtained from patients with bacteraemia or skin and skin-structure infections collected in more than 30 medical centres in the USA and Canada over a 10-year period (1997-2006). Fusidic acid was ver...

journal_title：International journal of antimicrobial agents

authors： Pfaller MA,Castanheira M,Sader HS,Jones RN

更新日期：2010-03-01 00:00:00

abstract：:We evaluated the efficacy of amphotericin B (1.5mg/kg/day), voriconazole (60mg/kg/day) and posaconazole (60mg/kg/day) in a murine model of systemic infection caused by Neoscytalidium dimidiatum. All the treatments were able to prolong survival and to reduce the tissue burden in the spleen and kidneys of infected mice....

journal_title：International journal of antimicrobial agents

authors： Ruíz-Cendoya M,Madrid H,Pastor J,Guarro J

更新日期：2010-02-01 00:00:00

abstract：:In this study, 2275 clinical isolates of 49 species of non-tuberculous mycobacteria isolated in The Netherlands were subjected to standardised drug susceptibility testing using the Middlebrook 7H10 agar dilution method. Clarithromycin and rifabutin were most active, with 87% and 83% of all isolates, respectively, bein...

journal_title：International journal of antimicrobial agents

authors： van Ingen J,van der Laan T,Dekhuijzen R,Boeree M,van Soolingen D

更新日期：2010-02-01 00:00:00

abstract：:In this study, we analysed the antimicrobial susceptibility of 92 strains of Achromobacter spp. isolated from clinical samples to 18 antimicrobial agents. The disk diffusion method and Etest were compared with the agar dilution method, and the breakpoints of susceptibility and resistance for the disk diffusion method ...

journal_title：International journal of antimicrobial agents

authors： Almuzara M,Limansky A,Ballerini V,Galanternik L,Famiglietti A,Vay C

更新日期：2010-01-01 00:00:00

abstract：:Toxin-producing gram-positive bacteria are responsible for emerging and life-threatening infections in humans worldwide. Both rapid toxin detection and adapted therapy are essential to limit the morbidity due to such toxins, especially staphylococcal Panton-Valentine leukocidin (PVL). Here we describe the use of a mas...

journal_title：International journal of antimicrobial agents

authors： Bittar F,Ouchenane Z,Smati F,Raoult D,Rolain JM

更新日期：2009-11-01 00:00:00

abstract：:Twenty-five years after its introduction, ceftazidime remains the most active cephalosporin against Pseudomonas aeruginosa. Nevertheless, resistance arises by upregulation of AmpC beta-lactamase, by efflux or, less often, via acquisition of additional beta-lactamases. Mutational resistance is especially prevalent amon...

journal_title：International journal of antimicrobial agents

authors： Livermore DM,Mushtaq S,Ge Y,Warner M

更新日期：2009-11-01 00:00:00

abstract：:Management of community-origin complicated intra-abdominal infections (cIAIs) requires surgical intervention and antimicrobial therapy. This multinational, randomised, double-blind clinical trial carried out in Asia compared the efficacy and safety of moxifloxacin monotherapy and ceftriaxone/metronidazole combination ...

journal_title：International journal of antimicrobial agents

authors： Solomkin J,Zhao YP,Ma EL,Chen MJ,Hampel B,DRAGON Study Team.

更新日期：2009-11-01 00:00:00

abstract：:The proportion of non-albicans candidaemia has increased during recent decades, especially Candida glabrata. We evaluated the antifungal susceptibility, clinical features and outcome of C. glabrata fungaemia treated in a tertiary centre in Taiwan. All episodes of C. glabrata fungaemia during 1999-2005 were identified ...

journal_title：International journal of antimicrobial agents

authors： Ruan SY,Huang YT,Chu CC,Yu CJ,Hsueh PR

更新日期：2009-09-01 00:00:00

abstract：:The genetic basis of erythromycin resistance in Turicella otitidis, a coryneform bacteria associated with otitis, was studied in five macrolide-resistant clinical isolates. Macrolide resistance genes were searched for by polymerase chain reaction (PCR). Genes for domain V of 23S rRNA (rrl) as well as rplD (L4 protein)...

journal_title：International journal of antimicrobial agents

authors： Boumghar-Bourtchai L,Chardon H,Malbruny B,Mezghani S,Leclercq R,Dhalluin A

更新日期：2009-09-01 00:00:00

abstract：:The worldwide epidemic of antibiotic resistance is in danger of ending the golden age of antibiotic therapy. Resistance impacts on all areas of medicine, and is making successful empirical therapy much more difficult to achieve. Antibiotic choices are often severely restricted, and the pipeline of new antibiotics is a...

journal_title：International journal of antimicrobial agents

authors： Gould IM

更新日期：2009-08-01 00:00:00

abstract：:Skin and soft tissue infections (SSTIs) are common and range in severity from minor, self-limiting, superficial infections to life-threatening diseases requiring all the resources of modern medicine. The classification of SSTIs can be based on the anatomical site, clinical severity or microbial cause, but some classif...

journal_title：International journal of antimicrobial agents

authors： Dryden MS

更新日期：2009-07-01 00:00:00

abstract：:The effect of subinhibitory concentrations of amikacin and ciprofloxacin on the susceptibility of Escherichia coli strains to the bactericidal action of normal human serum, outer membrane protein (OMP) expression and cell morphology was investigated. Sub-minimal inhibitory concentrations (sub-MICs) of both antibiotics...

journal_title：International journal of antimicrobial agents

authors： Wojnicz D,Cisowska A

更新日期：2009-06-01 00:00:00

abstract：:Carbapenem-resistant Acinetobacter spp. are being increasingly reported worldwide, including in South Korea, where we examined 144 representative isolates collected in a nationwide hospital survey in 2005. Metallo-beta-lactamases were detected in only 19.4% of isolates, none of which were Acinetobacter baumannii, wher...

journal_title：International journal of antimicrobial agents

authors： Lee K,Kim MN,Choi TY,Cho SE,Lee S,Whang DH,Yong D,Chong Y,Woodford N,Livermore DM,KONSAR Group.

更新日期：2009-06-01 00:00:00

abstract：:Multidrug-resistant and extensively drug-resistant tuberculosis (MDR/XDR-TB) are problematic to manage, especially in patients with acquired immune deficiency syndrome (AIDS). There is therefore a dire need for effective anti-MDR/XDR-TB agents. We have previously shown that agents that inhibit the efflux pumps of MDR ...

journal_title：International journal of antimicrobial agents

authors： Martins M,Viveiros M,Ramos J,Couto I,Molnar J,Boeree M,Amaral L

更新日期：2009-05-01 00:00:00

abstract：:Helicobacter infection, one of the most common bacterial infections in man worldwide, is a type 1 carcinogen and the most important risk factor for gastric cancer. Helicobacter pylori bacterial factors, components of the host genetics and immune response, dietary cofactors and decreased acid secretion resulting in bac...

journal_title：International journal of antimicrobial agents

authors： Stoicov C,Saffari R,Houghton J

更新日期：2009-05-01 00:00:00

abstract：:Non-toxigenic strains of Clostridium difficile are highly effective in preventing toxigenic C. difficile infection in hamsters when given following a single dose of an antimicrobial agent. The goal of this study was to determine the ability of non-toxigenic C. difficile to colonise hamsters during administration of an...

journal_title：International journal of antimicrobial agents

authors： Merrigan MM,Sambol SP,Johnson S,Gerding DN

更新日期：2009-03-01 00:00:00

abstract：:To describe the relationship between the ratio of the 24-h area under the concentration-time curve (AUC(24)) to minimum inhibitory concentration (MIC) as well as the effect of linezolid on Staphylococcus aureus, the killing kinetics of three S. aureus strains was studied by in vitro simulation of 5-day antibiotic dosi...

journal_title：International journal of antimicrobial agents

authors： Strukova EN,Smirnova MV,Vostrov SN,Lubenko IY,Firsov AA,Zinner SH,Portnoy YA

更新日期：2009-03-01 00:00:00

abstract：:New, aggressive forms of immunosuppression and an increasing population of patients at risk provide fertile ground for opportunistic invasive fungal infections (IFIs). Particularly challenging is the changing epidemiology of IFIs: rare pathogens are now more common and resistant strains are emerging among species that...

journal_title：International journal of antimicrobial agents

authors： Groll AH,McNeil Grist L

更新日期：2009-02-01 00:00:00

abstract：:Sepsis is a common and severe medical condition with substantial associated morbidity, mortality and cost. Furthermore, the incidence of sepsis has been rising annually over the past three decades, and morbidity and mortality remain high. The management of sepsis is further complicated by its very heterogeneous nature...

journal_title：International journal of antimicrobial agents

authors： Tsalik EL,Woods CW

更新日期：2009-01-01 00:00:00

abstract：:The treatment of bloodstream infections remains a significant challenge, with persisting high mortality and morbidity. To optimize antimicrobial therapy, the clinician must possess knowledge of the pharmacokinetic and pharmacodynamic properties of commonly used antimicrobials, and how these parameters may be affected ...

journal_title：International journal of antimicrobial agents

authors： Scaglione F

更新日期：2009-01-01 00:00:00

abstract：:Control of dental plaque-related diseases has traditionally relied on non-specific removal of plaque by mechanical means. As our knowledge of oral disease mechanisms increases, future treatment is likely to be more targeted, for example at small groups of organisms, single species or at key virulence factors they prod...

journal_title：International journal of antimicrobial agents

authors： Allaker RP,Douglas CW

更新日期：2009-01-01 00:00:00

abstract：:Globally, antibiotic resistance continues to be an increasing problem. The emergence of methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), and extended spectrum beta-lactamase-producing Enterobacteriaceae has seriously reduced the number of empirical agents suitable for selecte...

journal_title：International journal of antimicrobial agents

authors： Isturiz R

更新日期：2008-12-01 00:00:00

abstract：:Aspergillus flavus is the second most common Aspergillus spp. causing invasive infections in immunocompromised patients. Extensive prophylactic use of voriconazole (VCZ) in immunocompromised patients may enhance the selection of VCZ-resistant clinical isolates of A. flavus, compromising the effectiveness of this antif...

journal_title：International journal of antimicrobial agents

authors： Krishnan-Natesan S,Chandrasekar PH,Alangaden GJ,Manavathu EK

更新日期：2008-12-01 00:00:00

abstract：:The purpose of this study was to characterise the metallo-beta-lactamase VIM-6 and the genetic environment of the bla(VIM-6) gene. The bla(VIM-6) gene was cloned into an Escherichia coli expression system and the purified VIM-6 enzyme was obtained. VIM-6 has an isoelectric point of 4.9 and a molecular weight of 28.368...

journal_title：International journal of antimicrobial agents

authors： Koh TH,Yamaguchi K,Ishii Y

更新日期：2008-11-01 00:00:00

abstract：:Renal, liver, heart and lung transplantation are now considered to be the standard therapeutic interventions in patients with end-stage organ failure. Infectious complications following solid organ transplantation (SOT) are relatively common owing to the transplant recipient's overall immunosuppressed status. The inci...

journal_title：International journal of antimicrobial agents

authors： Salavert M

更新日期：2008-11-01 00:00:00

abstract：:Antimicrobial resistance is a major health problem worldwide, but marked variations in the resistance profiles of bacterial pathogens are found between countries and in different patient settings, especially in Asia. In Taiwan, the strikingly high prevalence of resistance to macrolides and streptogramins in clinical i...

journal_title：International journal of antimicrobial agents

authors： Huang YT,Hsueh PR

更新日期：2008-11-01 00:00:00

abstract：:This study investigated the phenotypic and genetic properties of 28 clinical isolates of metallo-beta-lactamase (MBL)-producing Chryseobacterium indologenes recovered from a university hospital. Twenty isolates were confirmed to carry a bla(IND) gene. Among them, 9 isolates were confirmed to carry the IND-1 gene, 10 c...

journal_title：International journal of antimicrobial agents

authors： Lin XH,Xu YH,Cheng J,Li T,Wang ZX

更新日期：2008-11-01 00:00:00

abstract：:Meticillin-resistant Staphylococcus aureus (MRSA), both hospital-acquired and community-acquired MRSA (CA-MRSA) strains, have increased in frequency in the last few years, reaching epidemic dimensions. This review discusses several clinical forms of staphylococcal infection leading to bacteraemia in a high proportion ...

journal_title：International journal of antimicrobial agents

authors： Rubinstein E

更新日期：2008-11-01 00:00:00

abstract：:Pneumococcal infections elicited by Streptococcus pneumoniae (pneumococcus) (pneumonia, otitis media, sinusitis, meningitis) are frequently occurring diseases that are associated with considerable morbidity and mortality even in developed countries. Pneumococci colonise the nasopharynx of up to 50% of children, and up...

journal_title：International journal of antimicrobial agents

authors： Pletz MW,Maus U,Krug N,Welte T,Lode H

更新日期：2008-09-01 00:00:00

abstract：:In the present study, Brucella melitensis biovar Abortus 2308 and Brucella abortus 3196 biotype 5 reference strains, which are susceptible to fluoroquinolones, became in vitro-resistant to fluoroquinolones by culture in trypticase soy agar. The quinolone resistance-determining regions (QRDRs) of the gyrA and parC gene...

journal_title：International journal of antimicrobial agents

authors： Turkmani A,Psaroulaki A,Christidou A,Chochlakis D,Tabaa D,Tselentis Y

更新日期：2008-09-01 00:00:00

abstract：:Citrobacter freundii strain 4306 was isolated from a urine specimen of a patient in March 2006 in Palestine. This strain showed a unique multidrug resistance phenotype, as it was resistant both to 7-alpha-methoxy- and oxyimino-cephalosporins, including cefepime, cefpirome and monobactams, in addition to quinolones, st...

journal_title：International journal of antimicrobial agents

authors： Ahmed AM,Shimamoto T

更新日期：2008-09-01 00:00:00

abstract：:Macrolide monotherapy is currently recommended as first-line treatment of mild-to-moderate community-acquired pneumonia (CAP) in penicillin-intolerant/allergic individuals in the UK. However, resistance rates among the commonest cause, Streptococcus pneumoniae, now exceed 10% in the UK and a review of alternative agen...

journal_title：International journal of antimicrobial agents

authors： Ludlam HA,Enoch DA

更新日期：2008-08-01 00:00:00

abstract：:Demonstration of efflux of ethidium bromide (EtBr) has been made for over 30 bacterial species, usually by showing enhanced efflux in multidrug-resistant strains that was then abolished by inactivating efflux pumps. Here we present a relatively simple automated method that employs EtBr as an efflux pump substrate for ...

journal_title：International journal of antimicrobial agents

authors： Viveiros M,Martins A,Paixão L,Rodrigues L,Martins M,Couto I,Fähnrich E,Kern WV,Amaral L

更新日期：2008-05-01 00:00:00

abstract：:Respiratory tract infections (RTIs) form a substantial clinical and financial burden, with the increasing complication of antimicrobial resistance. This resistance may compromise the use of many empirically prescribed antimicrobials. The new respiratory fluoroquinolones have been developed to overcome this burgeoning ...

journal_title：International journal of antimicrobial agents

authors： Blondeau JM,Tillotson G

更新日期：2008-04-01 00:00:00

abstract：:The role of membrane permeabilisation and disruption in the mechanism of action of some polymyxin analogues against Gram-negative organisms is contentious. The effects of polymyxin B (PMB) and its analogue polymyxin B nonapeptide (PMBN) on Escherichia coli envelopes should correlate, but previous work by other workers...

journal_title：International journal of antimicrobial agents

authors： Sahalan AZ,Dixon RA

更新日期：2008-03-01 00:00:00

abstract：:The in vitro susceptibilities to several antibiotics of 136 Escherichia coli strains containing virulence factors isolated from children with urinary tract infection were analysed. Escherichia coli strains were analysed by multiplex polymerase chain reaction for genes encoding the following virulence factors: pyelonep...

journal_title：International journal of antimicrobial agents

authors： Arisoy M,Rad AY,Akin A,Akar N

更新日期：2008-02-01 00:00:00

abstract：:Development of tuberculosis (TB) is a concern in patients who receive glucocorticosteroids for the treatment of chronic rheumatic or pulmonary diseases. However, the incidence of development of TB in such patients and the prophylactic role of isoniazid (INH) are unclear. We evaluated the available evidence from 20 rel...

journal_title：International journal of antimicrobial agents

authors： Falagas ME,Voidonikola PT,Angelousi AG

更新日期：2007-12-01 00:00:00

abstract：:This study evaluated the activity of colistin, rifampicin, imipenem and sulbactam/ampicillin alone or in combination against nine epidemic multidrug-resistant Acinetobacter baumannii isolates producing OXA-58 carbapenemase in Naples, Italy. The isolates were susceptible to colistin but differed in their resistance to ...

journal_title：International journal of antimicrobial agents

authors： Tripodi MF,Durante-Mangoni E,Fortunato R,Utili R,Zarrilli R

更新日期：2007-12-01 00:00:00